| ORIGINAL ARTICLE |
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| Year : 2022 | Volume
: 16
| Issue : 4 | Page : 280-292 |
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Vatari guggulu and mahaushadhi kwatha in amavata (Rheumatoid Arthritis): An open-label, single-arm clinical study
Vibhu Powar1, Girish Koppa Jayaprakash1, Lakshmiprasad L Jadhav1, KS Sreedevi1, Rashmi Bhatt2
1 Department of Kayachikitsa, Sri Dharmasthala Manjunatheshwara College of Ayurveda and Hospital, Hassan, Karnataka, India
2 Department of Samhita and Siddhanta, Sri Dharmasthala Manjunatheshwara College of Ayurveda and Hospital, Hassan, Karnataka, India
Correspondence Address:
Vibhu Powar
Department of Kayachikitsa, Sri Dharmasthala Manjunatheshwara College of Ayurveda and Hospital, Hassan - 573 201, Karnataka
India
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/joa.joa_157_21
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Introduction: Amavata (rheumatoid arthritis [RA]) is a painful disease which is caused due to vitiated vata and Ama. Amavata has been correlated to RA in modern medical parlance. The prevalence of RA in adults of the developed world is around 0.5%–1%, amid which around 40% are registered disabled within 3 years, while around 80% are moderate to severely disabled within 20 years. Based on the pathogenesis of Amavata, the treatment shall be focused mainly on ama-pachana (digestive) and agni dipana (carminative). Most of the ingredients in vatari guggulu and mahaushadhi kwatha are katu (pungent), tikta (bitter) rasa (taste), and ushna virya (hot potency), which helps in ama pachana (digestive) and agni dipana (carminative) action. Ingredients namely gandhaka (Sulphur), guggulu (Commiphora mukul), haritaki (Terminalia chebula), and amalaki (Emblica officinalis) are having rasayana property; while shunti (Zingiber officinale), guduchi (Tinospora cordifolia), guggulu, haritaki, vibhitaki (Terminalia bellerica), and amalaki have anti-inflammatory property. Methods: Thirty patients were administered vatari guggulu 1 tablet (1 g) along with mahaushadhi kwatha 15 ml thrice daily after food with warm water as anupana (adjuvant) for 15 days. Ordinal data were analyzed with Friedman's test followed by Wilcoxon sign rank test as post hoc; continuous data were analyzed with repeated measures ANOVA after applying Bonferroni correction with paired t-test as post hoc. Results: There was statistically significant improvement in the primary outcome measures, in disease activity and functional ability indices. Conclusion: Vatari guggulu and mahaushadhi kwatha are effective in the management of Amavata.
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