Introduction: Yesaka Liquid is an Ayurvedic Proprietary formulation containing multiple standardized herbal extracts like Triphala (3 myrobalans), Jamun (Eugenia jambolana), Kutki (Picrorhiza kurrooa), Haridra (Curcuma longa) etc., having potential anti-diabetic and anti-oxidant properties. The evaluation of clinical efficacy and safety of Yesaka Liquid as an Add-on therapy to oral hypoglycemic agents (OHAs) in Type II diabetics was the primary objective of the study. Methods: After obtaining ethical approval and informed consent, at five study sites, 112 patients were randomized in two study groups. The patients in Add-on Group were given Yesaka Liquid along with OHAs while those in the Control Group were asked to continue with the on-going OHA (s) for 90 days. The assessment of efficacy was done by estimation of HbA1c%, quality of life (QOL) on WHO-QOL BREF questionnaire, plasma glucose, serum insulin, symptoms of diabetes mellitus, anthropometric measurements, and changes in homeostatic model assessment for insulin resistance score. The assessment of safety was done by clinical review of all safety parameters and safety-related laboratory parameters. Global assessment of overall safety and tolerability by the physician and patient was also done. Results: Yesaka liquid was found to be effective as add-on therapy to OHAs in type II DM management by controlling the levels of HbA1c and blood sugar. It showed significant effect in reducing various symptoms of type II DM and also improved the QOL of patients. Conclusion: Yesaka Liquid can be recommended as an effective and safe formulation for the management of type II DM as an odd-on therapy.

Introduction: Comparative role of different Ayurveda therapies in the treatment of female infertility. Methods: It was an open-label, comparative, randomized trial. Thirty female patients were equally divided into two groups as Group A, treated with Virechana karma (Purgation therapy) followed by yoga basti (Ayurveda enema therapy) regimen and Group B treated with Yoga basti followed by Uttarabasti (Ayurveda intrauterine therapy) regimen. In Group A, Virechana was done with Tilvakaghrita followed by Erandmooladi yoga basti and in Group B Erandmooladi yoga basti was administered followed by Uttarabasti with Bala taila. The variables used for assessments were conception, grading in menstruation parameters, spinnbarkeit (SB) test, fern test, follicular study, and endometrial thickness. For intragroup comparison, “Wilcoxon matched-paird signed-ranks test” and “paired t-test” were used. For intergroup comparison, “Mann–Whitney test” and “unpaired-t-test” were used. All the statistical tests were interpreted as significant at 5% level (P < 0.05). Results: The median age of these participants was 28 years (range, 20–36). In Group A, there were statistically significant improvements in the follicular study, SB test, menstrual parameters, and dyspareunia after the trial. In Group B, there were statistically significant improvements in endometrial thickness, Fern test, SB test, amount of menstruation, duration of menstruation, and dysmenorrhea. On comparison, there was a statistically insignificant difference between these two groups in the outcome. Conclusion: Ayurveda purgation-enema therapies and Ayurveda enema-intrauterine therapies are equally effective in the management of female infertility.

Introduction: Nadi Pariksha or pulse examination is one of the important tools for the examination of a healthy and in diseased person which has been recognized not only in ancient systems of medicines but also in the contemporary medicine. It has been included under Ashtavidha Rogi Pariksha by Yogaratnakar which itself signifies its importance, as it is ranked 1^st. Methods: Moreover, Ayurveda scholars have many aspects of Nadi Pariksha, many of which are still unexplored. Thus, this exploratory study was designed and done with aim to find out any variation in parameters of Nadi and pulse in accordance with Prakriti. 200 healthy volunteers, willing to participate in the study were selected through purposive sampling method and were subjected for the assessment of Prakriti, Nadi, and pulse examination. Results: It was observed that only few parameters do vary statistically in accordance with Prakriti. Secondly, it was also observed that Nadi and Prakriti are showing some correlation. Irregular pulse was observed in persons having Vata Prakriti by using manual method. While regular pulsation was observed in the persons having Pitta and Kapha Prakriti. Mean value of pulse rate observed maximum in Pitta Prakriti and minimum in Kapha Prakriti persons by manual method. Conclusion: Although it was exploratory study, some relation between Nadi, Pulse and Prakriti has been observed but few of them were not found statistically significant. Second, the difference in observation through Nadi Tarangini method and manual method might have occurred due to the small sample size. Therefore, more researches may be conducted with larger sample size. It can be also said that Nadi and Prakriti are independent parameters and they are showing some correlation.

Introduction: Our main aim is to adopt the holistic approach of Ayurveda in the prevention of disease before to treat the cause. Because of changing lifestyle and environmental conditions skin diseases are markedly increased in number. Aims and Objectives: To assess the effect of Ahara (diet) and Vihara (life style) on Kushtha (skin disease) through conceptual study and survey study is applied on clinical grounds. Methods: In the present study, etiological-based survey of 90 patients who visited in the outpatient department and inpatient department of the Department of Agad Tantra (Ayurveda Toxicology) National Institute of Ayurveda was carried out to assess the dietary and habitual lifestyles of people suffering from Kushtha (skin disease). The study was interview-based survey on simple randomized selection of patients. In the present study, an etiology-based survey questionnaire was prepared based on classics to assess dietary and habitual lifestyles of people suffering from skin disease. Results: In the present clinical study, maximum number of patients having mandagni. Aam rasa is produced due to mandagni, which is stated as the prime cause for almost all diseases. Viruddahara, Mithyahara-vihara are perceived as major causative factors in observation during the study. Conclusion: Avoidance of these aetiologies is concluded to be the first step in the direction of control and management of Kushtha (skin disease). As Ahara and its related codes and conducts have been long forgotten by the human being; therefore, this study was undertaken to evaluate and rediscover this ancient science of dietetics in Ayurveda both conceptually and clinically.

Introduction: With the lack of evidence-based specific therapy for COVID-19, the prevention against the infection and boosting the body's immunity is the only option. Experts have suggested the use of herbal plants to boost the immunity; however, the use and acceptance of herbal medicinal plants among young adults are not known. The present study is aimed at assessing the use of herbal medicinal preparations as immunity booster among young adults during the times of COVID-19 pandemic. Methods: A cross-sectional study was conducted among college-going students during October 23–31, 2020. A Google form was circulated to the target group through the private and institutional networks during the study period. The questionnaire consisted of questions related to past, current, and future use of the herbal medicinal preparations. Data were extracted in MS-Excel. Univariate analysis and logistic regression was performed using the SPSS software version 21. Results: A total of 318 participants with a mean age of 20.5 ± 2.1 and approximately 79% females were included in the analysis. Of the total, 65.7% participants stated some use of herbal preparations as the immunity booster during the pandemic. Type of family, monthly income of the family, and state of residence were not found to be significantly associated with the use of herbal medicinal plants during the pandemic, whereas the past use of herbal medicines, participants who considered herbal medicinal plants to be effective and safe were found to be significantly associated with the use of herbal preparations during the pandemic. Conclusion: A significantly large proportion of young adults are using herbal medicinal plants as immunity booster during the pandemic indicating inclination toward traditional medicines.

Introduction: Health is the main concern for all and it is taking on serious note now a days. The potential deleterious effects of environmental chemical exposure caused serious and high concern threat to the life which indeed has gained considerable interest for research works. Cauliflower (Brassica oleracea var. botrytis L.) is one such vegetable where the maximum spraying of pesticides is in practice. There are undeniable evidences regarding the hazardous effects of the sprayed pesticides. Ayurveda has explained the purification measures for all kinds of articles which are poisoned or mixed with chemical. Objective: The present study was carried out to analyze the effect of washing processing on the reduction of pesticide residues in cauliflower through the gas chromatography–mass spectrophotometry (GC-MS). Residual level of pesticides in cauliflower after washing with tap water and medicated water was analyzed. Methods: Each cauliflower was divided into three samples and different washings were compared with the control sample. Results: The results of the present study showed that using medicated water, we can be able to have less contaminated cauliflower vegetable. It was concluded from this study that traditional processing methods play a significant role in the reduction of pesticides such as prefenofos and indoxicarb which are really harmful when taken fortunately and frequently with food. Conclusion: Medicated water sample was appreciated to been efficient method of washing is evidenced by the GC-MS. Hence, an attempt was made at such level to create the awareness about the same and follow traditional methods for washing vegetables.

Introduction: Psoriasis (kitibha) is characterized by chronic inflammation and epidermal hyperplasia where mast cells and tryptase are activated with related form of cytokines. Cipadessa baccifera (Roth.) Miq. (Meliaceae family) is an ethnomedicinal plant reported for its anti-psoriatic tribal claim. In the present study, in silico docking study was planned for proven clinical use of C. baccifera in psoriasis with identified phytoconstituents. Methods: Eight identified well-known phytochemicals from the leaf of C. baccifera were used. The molecular docking studies were performed using iGEMDOCK2.1. Drug likeness of the compounds was predicted using Swiss ADME while in silico toxicity studies were performed using ProTox-II online tool. Results: All of retrieved eight phytoconstituents of C. baccifera possesses drug likeness properties. Phytoconstituents are nontoxic in nature and showing bioavailability, having significant inhibitory activities on validated anti-psoriatic targeted proteins, 2ZEB (Human Mast Cell Tryptase) and 2AOT (Histamine methyltransferase). Conclusion: The results of present study suggest the potential clinical role of C. baccifera in psoriatic patients and thus, proved the traditional claim through in silico docking study.

Objective: Sedentary lifestyle, unhealthy dietary habit such as excessive intake of fast foods, cold-drinks, liquors, smoking, irregularity of diet intake are the major causative factors for many lifestyle diseases such as obesity, which disturbs physical, mental as well as social health of an individual. The drugs used to treat obesity in modern medical science have several side effects and have a chance of weight gain again after the certain time limit of medication stoppage. The drug therapy is incomplete in itself, so Pathya Ahara (Wholesome diet) and Pathya Vihara (Lifestyle) need to be properly followed to manage obesity. The study aimed to review and categorize the wholesome (Pathya) food articles and lifestyle for Sthaulya (obesity) mentioned in Ayurveda Classics. Data Source: Ayurveda classics (mainly Brihattrayi Classics) were referred to review the wholesome (Pathya) food articles and lifestyle for Sthaulya (Obesity). Review Methods: The food articles and lifestyle mentioned in classics as Pathya (Wholesome) for Sthaulya were reviewed and organized as per various categories of food articles mentioned in Ayurveda. Results: In Ayurveda, obesity has been described as Sthaulya or Medoroga. It is described under the caption of Santarpanottha Vikara. Acharya Charaka has described the use of the Guru and Atarpana diet as a special regimen for Sthaulya. Various categories of diet like fruits, cereals, pulses, vegetables, sugarcane products, alcoholic and fermented food items, salt, oil, and spices, used to prepare food along with lifestyle such as proper sleep, exercise, Yogasana and Pranayama have been advised to manage the obesity. Conclusion: Wholesome diet from various categories of afore mentioned food articles as well as a lifestyle like proper sleep, regular exercise, and practice of Yoga can help to reduce the weight to obese persons.

Objective: Ayurveda the primitive and preventative science elucidated adharneeya (nonsuppressible) Vega (natural urges) to prevent and restrain diseases. Vega plays a major role in the proper functioning of the body. They are regulated mainly by Vata with the support of other subtype of dosha and the controlled and guided activities of mind. Vega Dharana is considered as the contributory cause of many chronic diseases and acute physiological conditions. Data Source: Classical Ayurvedic texts along Charka are searched to interpret the Ayurvedic physiology of each Vega. Review Methods: Both Ayurveda and modern recent researches on natural Vega, and their therapeutic significance is explored through electronic search. Result: Understanding the physiology of Adharneeya Vega is crucial for the etiopathogenesis of their consequences and other related diseases described by Ayurveda classics. Conclusion: In the present article, an attempt has been made to explore the concept of adharaneeya Vega mentioned in Charaka samhita with contemporary relevance in clinical Ayurveda practice and thereby aid in health promotion and also as a preventive tool.

Objectives: To identify and explore the Apathya and Pathya according to the Srotasa in Jwara. Data Source: Charak Samhita Vimana Sthana and Charaka Samhita Chikitsa Sthana, available all Sanskrit commentaries on Charak Samhita, and other commentary on Astanga Sangrah and Astanga Hridaya Samhita. Review Methods: Profound explorative review study of all collected material using offline and online available texts. Result and Conclusion: One year old Cereals and pulses, husked grains Mudga (Phaseolus aureus), Jeevanti, Solanum nigram, (Kakamachi), Corchorus capsularis, Centella asiatica (Brahmi), (Mandukaparni), Trichosanthes dioica (Patola) are some vegetable and dietary substance to be used.

Background: Hemadri, the prominent minister of King Mahadeva and Ramdeva of Devagiri, Maharashtra, was very eminent scholar belonging to the 13^th–14^th century. He has written many scholarly books and Ayurvedarasayana commentary on Ashtangahridayam is considered his masterpiece. Objective: The objective of this study is to enlighten the contribution of Acharya Hemadri in the field of Ayurveda. Data Source: The books, i.e., Ayurvedarasayana commentary on Ashtangahridayam, Life of Hemadri, Vagbhatavimarshah, KashyapasamhitaUpodghata, etc., have been reviewed. Review Methods: Thorough study of data source followed by critical and rational analysis of the life and works of Hemadri. Results and Conclusion: The commentary is incomplete, but it is written with a practical approach and the author has amended the order of chapters and has organized it more systematically. The remarkable features of his commentary are the reorganization of Nidanasthana and Chikitsitasthana in such a way that after each chapter of Nidanasthana the corresponding Chikitsita is explained.

Introduction: Urinary tract infection during pregnancy and postpartum is a common obstetric complication. The term Mutrakruchhacomes under the disorders of MutravahaSrotas, and mainly deals with shool (pain) and krucchrata (dysuria). This article discusses a female patient with a history of 6 months 24 days of pregnancy seen in the OPD of Prasuti Tantra, Sir SundarlalHospital, IMS, BHU. Main Clinical Finding: Her chief complaints were painful, difficult urination with burning along with pain in the suprapubic region for 8 days. Diagnosis: In this case, the patient has an urge to micturate, but she passes urine with pain. The painful voiding of urine is diagnosed as Mutrakruchha. Interventions: After appropriate analysis based on ayurvedic and modern parameters, the patient was treated with Trinapanchmulakwath. Outcome: Before treatment, her scoring of subjective parameters was 13 and after treatment, her score decreased to 2. Thus, the treatment module showed significant relief in the symptoms by 84.62%. Laboratory investigation showed marked improvement as pus cells were reduced to 0–1/high power field (HPF) from 10 to 12/HPF and epithelial cells were reduced to 1–2/HPF from 9 to 10/HPF. Conclusions: All the symptoms and investigations showed highly significant results, hence it can be concluded that this medicine is very effective in patients of garbhinimutrakruchha.

Introduction: Purpose of the study is to manage recurrent pharyngitis (Ekvrindamukharoga) because antibiotic resistance issue is a big concern as there is no permanent management in conventional medicine. Main Clinical Finding & Diagnosis: The present case was diagnosed with viral pharyngitis on basis of fever, sore throat &lymphocytosis. Interventions: TalishadiChurna, Mrityunjaya rasa, Laxmivilasa rasa & Tankana were administered for 3 days and subsequently Vamana (~induced therapeutic vomiting) was performed to prevent recurrence. Outcome: Major improvement recorded in oral temperature, color (beefy red to light pink), etc., after the intervention. Throat pain (from 5 point to 1) and swelling (from 2 to 1) after 2 h and were relieved completely after 3 days. Conclusion: This case study reports effective management of antimicrobial-resistant acute pharyngitis with stand-alone Ayurvedic therapy. Non-relapse of symptoms after Vamana during the follow-up period (6 months) emphasizes the effective secondary prevention achieved with Ayurveda.

Introduction: The presented case report depicts gradual revival of a patient with head trauma from semivegetative state with complete Ayurvedic treatment. Main Clinical Findings: The patient was in semivegetative state with least mobility, due to partial motor function loss, drowsiness, speech and memory loss, no sensation or control over micturition and defecation, and need of PEG tube for feeding. Diagnosis: Shirobhighatajanya Vatavyadhi and Sannyasa. Interventions: Complete Ayurvedic treatment was administered focusing on Vatashamana, Raktaprasadana, Agnideepana, Marmaparipalana, and Indriyaprabodhana. Outcome: Mobility, speech and memory improvement, oral solid food intake by herself, and proper sensation and control over micturition and defecation are the main satisfactory outcomes. Conclusions: Timely and complete Ayurvedic diagnosis and Ayurvedic treatment along with Chatushpada Sampatchikitsalaya are the key factors in treating chronic and critical conditions of Marmabhighata.