Background: Chronic suppurative otitis media (C.S.O.M.) is a chronic inflammation of the middle ear, which is the result of an initial episode of acute otitis media and characterized by the recurrent discharge from the middle ear through a tympanic perforation. In Ayurveda, C.S.O.M. can be correlated with Karnasrava. According to Acharya Sushruta, Karnasrava is "discharge of pus from a Vata affected ear which may result from a head injury or due to immersion in water or else due to suppuration or bursting of an abscess." In modern science, most of the approaches for the treatment of C.S.O.M. have been surgical, which are often expensive, complicated, and do not provide satisfactory hearing improvement; also these are inaccessible in many developing countries. Considering all these points, there is a need to search for an effective, preventive, and safe treatment. Objective: The objective of this study is to evaluate the efficacy of Karnapichu and Karnadhupana along with Rasnadi Guggulu on Karnasrava. Materials and Methods: A total of 30 patients with signs and symptoms of Karnasrava (C.S.O.M.) were registered and randomly divided into two groups: Group A: 15 patients were treated with Gandhaka Taila Karnapichu (8–16 drops) along with Rasnadi Guggulu orally for 30 days and Group B: 15 patients were treated with Karnadhupana locally and Rasnadi Guggulu orally for 30 days. Results: Both the groups showed highly significant results in the subjective parameters and nonsignificant results in the objective parameters of Karnasrava. Conclusion: Gandhaka Taila Karnapichu, Rasnadi Guggulu, and Karnadhupana are effective in the management of Karnasrava (C.S.O.M.).

Background: Renal calculi or kidney stone disease is a common painful urologic disease causing significant social and financial burden. It has high recurrence rate of nearly fifty (50%) percentage. Ayurveda textual references mention specific diuretic, lithotriptic medicines for Asmari (Renal Calculi) which can provide safe, effective and economical treatment. Aim: To evaluate the combined efficacy of Patala kṣhara (an alkaline powder prepared from ash of Stereospermum chelonoides) and Gokshurdi churna (herbal powder) in the disintegration and expulsion of renal calculus. Materials and Methods: The study was a pre and post clinical trial with 30 patients in a single group selected on the basis of specific inclusion and exclusion criteria (Ultrasonography [USG] evidence of renal calculi up to 8 mm size). They were imparted 500 mg Paṭala kshara capsule with lukewarm water and 6 g Gokshuradi churna with honey internally twice daily after food for a period of 30 days. Assessment were done on 15^th, 30^th and 60^th day for subjective parameters (pain, haematuria, burning micturition and increased frequency of micturition) and on 30^th day for objective parameters like size and number of stones and epidermal growth factor receptor. Results: Pain, dysuria, size and number of calculus is statistically significant with P < 0.000. Haematuria showed significance with P < 0.046, burning micturition and increased frequency of micturition were significant with P < 0.008. Conclusion: On analysing the results it can be concluded that Patala kshara and Gokshuradi churna are effective in disintegrating and expelling renal calculus. It is effective in reducing the size and number of stones as well as the clinical symptoms.

Background: Garbha Kshaya is considered among the abnormalities of fetus (Garbha Vyapads), associated with growth-related disorders, especially due to maternal undernourishment. Garbha Kshaya comprises of diminished fundal height (Anunnata Kukshi) and reduced fetal movement (Garbhaaspandana) possibly due to reduced liquor amni. Ayurveda mentions Ksheera Basti as classical treatment in its management, wherein nourishment is provided through milk-infused medicated enema. Materials and Methods: Pregnant patients fulfilling the inclusion criteria were randomly divided into two groups. Forty-one patients in Shatavaryadi Ksheerapaka Basti group (trial) were administered with Shatavaryadi Ksheerapaka Basti consisting of Bala, Shatavari and Arjuna for a period of 10 days daily once in the morning. Twenty patients in L-Arginine group (control) were administered with L-Arginine 6.5 g sachet BD (in divided dose) with 1 glass water for 10 days. Results: Improvement was observed in the fetal movements (P ≤ 0.001) and maternal wellbeing (P ≤ 0.001) in Ksheerapaka Basti group. Abdominal girth (P ≤ 0.001) and symphysis fundal height (P ≤ 0.001), and maternal weight gain (P ≤ 0.001) showed highly significant results in Ksheerapaka Basti group. Pregnancy related discomforts such as Adhmana (P ≤ 0.001), Anidra (P = 0.002), Aruchi (P ≤ 0.001), Bhrama (P = 0.009), Daurbalya (P ≤ 0.001), Gaurava (P ≤ 0.001), Katishoola (P ≤ 0.001), Malabaddhata (P ≤ 0.001), Padashoola (P ≤ 0.001), Padashopha (P ≤ 0.001), Shrama (P ≤ 0.001), and Uras Daha (P ≤ 0.001) showed significant improvement in Ksheerapaka Basti group. Conclusion: Shatavaryadi Ksheerapaka Basti showed encouraging results in improving the fetal movements, maternal weight, and growth measurements such as abdominal girth, symphisis fundal height. It also showed promising results in overcoming the physiological discomforts of pregnancy and maintaining the overall maternal health.

Background: Knee is subjected to constant stress during everyday activities. In various occupations, position influences its structure and function. Heavy vehicle driving is one such occupation that exerts strain on the musculoskeletal system of the body, especially knees. The objective of this study was to assess the effect of heavy vehicle driving as occupation on the structure of knee. Methodology: It is a comparative, cross-sectional observational study. Twenty-five heavy vehicle drivers and 25 persons of other occupations were included in the study. After history and clinical examination of both knees, range of motion (ROM) was calculated by goniometer. X-ray of both knees (anteroposterior and lateral views) was done. Assessment was done based on findings of X-ray, ROM, knee pain, and inflammation. Results: Pain, stiffness, crepitations, reduced joint space, painful and restricted movements, development of osteophytes, and subchondral sclerosis of knee joint were more in heavy vehicle drivers as compared to subjects of other occupations. Changes suggestive of osteoarthritis of knee changes were more in heavy vehicle drivers when compared with other occupations. Conclusion: Heavy vehicle drivers may suffer from degenerative changes in knee with respect to its anatomical structures and biomechanics when compared to other occupations. Duration of driving and daily driving hours was found to have influence on the health of knee.

Introduction: Now a days, the world's population is facing a lot more psychological problems than physical suffering. "Quality of life" refers to a subjective evaluation which is embedded in a cultural, social, and environmental context. There is a strong relationship between brahma muhurta jagarana and healthy life. This concept needs to be elaborated and explained from the Ayurveda point of view as well as justified with modern views for which this study has been planned. Materials and Methods: Six hundred volunteers were divided into two equal groups having 300 volunteers who had been waking up in brahma muhurta and other 300 volunteers who had not been waking up in the brahma muhurta. The World Health Organization quality of life-BREF was analyzed and compared in both groups. Results: Quality of life, satisfy with health, enjoy in life, able to concentrate, enough energy, satisfied with sleep, and negative feeling have significant better result (P < 0.05) in brahma muhurta jagarana groups as compared to non brahma muhurta jagarana group. Conclusion: Brahma muhurta jagarana is an important part of dinacharya to be adopted to improve the quality of life.

Introduction: "Sarpgandha" or "Asrol" is the root of Rauvolfia serpentina (L.) Benth Ex. Kurz., which belongs to the family Apocynaceae. Conventionally, it is used in the treatment of several body ailments, viz., abdominal pain, circulatory disorders, dysentery, gastrointestinal disease, hypertension, mental illness, malaria, and snakebite, and as a uterine stimulant; however, its monoterpenoid indole alkaloid reserpine extracted from the root is used for the treatment of hypertension. The problem reported that, occasionally, stem or aerial part of the same plant adulterated along with the root. Therefore, the aim of the present study is to carry out pharmacognostic evaluation of "Sarpgandha" and its adulterant/substitute for quality control. Methods: Macromicroscopy, physicochemical parameters, and high-performance thin layer chromatography (HPTLC) profiling have been done. Results: The study showed that the root has dark vertical ridges on the surface whereas stem has no ridges but mark of nodes and internodes. Transverse section of the root shows highly sutured outer lining while that of the stem shows smooth lining. Powder microscopy showed cork cells and starch grains in the root while single and group of stone cells in the stem. All the studied physicochemical parameters present higher level in the root powder, except total moisture content. HPTLC densitometric profile shows alkaloid reserpine at retention factor 0.49 under UV254 and UV366 nm in the solvent system toluene: ethyl acetate: diethylamine (7:2:0.5) in the methanolic extract of the root. Conclusion: Quality control markers of "Sarpgandha" would be available for authentication of commercial samples.

Introduction: There can be no state of positive health and wellbeing without a good quality of water. Ayurveda explains many techniques for water purification which are easy to use, economical, and can be easily applied with household resources. Methods: Vessels made of brass, copper, stainless steel and earthen pot were used for the purpose. The physicochemical and microbiological qualities of the drinking water were analysed for each water sample collected during an initial time ("0" hr) and after 24 hr. Results: No change in the physical parameters of the water quality is observed in all vessels from initial "0" hr to after 24 hr. Absence of total fungal count is observed in water stored in three vessels, i.e., copper, earthen, and steel vessel from initial "0"hr to after 24 h. The organisms Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella abony are seen to be absent in all the four vessels in which water is stored from initial "0" h to 24 h. Conclusion: The results obtained in this study reveal that the quality of water stored in copper is better than others.

Objectives: Moringa oleifera Lam. (FamilyMoringaceae) is indigenous to sub-Himalayan tract and is commonly grown across the country. Numerous uses are mentioned in classics which revealed that the whole plant or its specific parts has been utilized as Sothahara (~decrease edema, Kusthaghana (~skin disease), Jawaraghana (~fever), Krimighana (Antihelmenthic) etc. Researches has been done on the potency of this plant which discloses activities of the extract and isolated molecules of this plant without any toxic effects such as antibacterial, antihelminthic, antifungal, antifertility, anticancer, antioxidant, hepato-protective, anti-arthritic, diuretic, antiviral etc. activities. Many phytochemicals have been also isolated from the different parts of this plant. The main objective of the present work is to highlight the potency of this plant as antibacterial antihelminthic, antifungal, antifertility, anticancer, antioxidant, hepato-protective, anti- arthritic, diuretic, antiviral etc. activities. Data Source: Ayurvedic texts, research journals and database. Review Methods: The Ayurvedic texts were scrutinized for the drug description and the recent researches from the journal and database were studied. Results: Present study revealed that there are numerous traditional uses, and evidences of pharmacological potency additionally the present review also illustrates its phytochemical profile, comparison between Ayurvedic and bio medicinal uses, which will be helpful for future researchers. Conclusion: But still it is underutilized established medicinal plant because its huge potentials are still uncovered like as in classical text property of this plant is stated as Grabhastravahara (Antiabortic) but in biomedicine research done which disclose abortifacient activity, for that reason there is demand for further research which based on its phytotherapeutical importance.

Introduction: Agni is the supreme entity residing in the living being responsible for digestion of four types of Aahaara (food). Jatharagni is the chief among all the categories of Agni, it should be suitably maintained. Ayurveda suggests that there are ample of factors like Manas that affects the normal function of Agni apart from Doshik influences. Objective: Chinta (anxiety) being one of the Manasa Bhava is supposed to have its influence on Agni, article attempts to understand influence of Chinta on Agni with supportive scientific & contemporary views. Data Source: Charaka Samhita, Sushruta Samhita, Ashtanga Hridaya, Modern human physiology textbooks and online data bases. Review Methods: The classical text books were reviewed manually and review was also done by referring various scientific journals and other databases. Results: Vatavruddhi occuring in Chinta can be correlated to activation of sympathetic system. Agnidushti & Samanavayu Dushti occurred in Chinta can be understood as decrease in activity of enzyme secretions and motility of GIT- which are necessary for digestion of food & movement of food in alimentary canal respectively. Thereby Chinta is the reason for impaired digestion of food & generation of different GIT disorders. Conclusion: Analytical review suggests that there is direct relationship of status of Manas(Mind) and Agni (Digestive fire).

Objective: The objective of this study is to provide an overview of the effects of pesticide exposure during pregnancy and to newly born baby with its possible management and preconceptional care through Ayurveda. Data Source: We visited Hisar, Sirsa, Faridabad, and Bhivani cities of Haryana state and interviewed some pregnant ladies and farmers who were in direct contact with pesticide in agriculture or pesticide industries; collected information and assessed its effect on their body. Data were collected from the related websites, conference proceedings, scientific or technical reports, and other documents from the Government of India to identify the relevant information. The detoxification methodology was adopted from the classical text books of Ayurveda and research articles. Review Methods: It is a descriptive literature review-related study. Results: The detail analysis suggests that the pregnant women have greater vulnerability to chemicals, however, may include toxic elements in diet poses health risks to both mother and child. Exposure to pesticides during pregnancy impairs growth and neurodevelopment of growing fetus. There are lot of opportunities can be explored through Panchkarma and medicinal plants described in Ayurveda for preconceptional detoxication Vishghna plants (antitoxic herbs) can prove to be a mile stone for detoxification. Conclusion: This study provides the advantages of detoxification before conception. It will be helpful in causing awareness among the masses about the harmful effects of pesticides exposure and the benefits of Ayurveda for detoxification.

Introduction: SARS-CoV-2, a global pandemic that caused significant morbidity and mortality worldwide, even in the second wave. Multiple factors influence the disease burden including the vicious circulating virus characteristics, complications, limitations of the existing medicine, aggravation of the disease, and comorbidities in older people. In the present scenario, effective traditional treatment modalities should be scientifically applied to reduce massive disasters. Objectives: Here is the necessity to develop an appropriate treatment protocol from the field of Ayurvedic medicine. Diagnosis: It is a case study of a confirmed case of COVID-19/SARS-CoV-2 with uncontrolled diabetic history. Significant Clinical Findings: Presented intermittent fever, cough, headache, and dyspnea, along with symptoms associated with diabetes mellitus. Interventions: The case was successfully managed with Ama pachana (~carminative), Agnideepana (digestive), Jwara hara Oushdha, and simultaneously Prameha (~diabetes mellitus). Outcomes: The entire treatment course competed with a minimum number of hospitals stay compared with the national average. Ayurvedic management has a significant positive impact on the mental and physical quality of life. Both physical and mental scores got improved by more than 50% in this case. Marked radiological improvement noted, in this case, is associated with excellent quality of life after treatment. Conclusion: Ayurvedic management can be used in multiple levels preventive, curative, and restorative aspects.

Introduction: Acne vulgaris has always been one of the most burning problems of the young population. Acne vulgaris like presentation in Ayurveda has been described as Shalmali thorn like eruptions on the face due to vitiation of Kapha, Vata, and Rakta under the heading of Mukhadushika. Very less scientific data is available depicting the effect of Ayurvedic intervention in such cases. Main Clinical Finding: Present case reports a 26 years old female having multiple acne for the past 6 months. She had papules and pustule with itching, pain, and blackish spots on cheeks. Diagnosis: Condition was diagnosed as Acne vulgaris (Ayurvedic diagnosis – Pitta-Kapha dominant Tridoshika Mukhadushika). Interventions: The patient was treated with Kaishor Guggulu, Raktaprasadakahima, and the local application of Terminalia arjuna powder mixed with honey daily for 1 month. Outcome: The patient had relief in all the symptoms after 15 days of treatment with no new eruptions. Complete remission of the disease was observed after 1 month of treatment with the improved skin condition. Conclusion: This case study demonstrates the potential and usefulness of Ayurveda in the management of acne vulgaris.

Introduction: Lichen planus pemphigoides (LPP) is a rare autoimmune sub-epidermal blistering disease associated with lichenoid skin changes. Here, a 52 years female patient diagnosed with LPP for the last 1.5 years was on steroid therapy treated successfully with ayurvedic interventions is being reported. Main Clinical Findings: Dermatological examination revealed hypertrophic, black to purple colored, round-to-oval papular, flat-topped, well-circumscribed lesions (2–5 mm), symmetrically distributed over upper and lower limbs. Psoriasis Area Severity Index (PASI) score was 34. Diagnosis: Blackish/purple lesions with roughness, itching and scaling correlated to Kitibha in classics. Interventions: Internal administration of decoction of Punarnava and Sahijana with Arogyavardhini vati and Tab Sumanta and external application of Apamarga kshara, Karanjadi and Somraji taila was prescribed as baseline treatment. Outcome: After 2 months of treatment, cessation of new lesions and marked reduction in itching and elevation was found. PASI score decreased to 9.6. In next follow-up, the elevation of lesions and symptoms completely declined and the skin reversed back close to normal texture. PASI score was also found 0. Conclusion: Ayurvedic interventions have proven effective potential in treating rare autoimmune disease like LPP.